Work

Drug-Drug Interactions at Organic Cation Transporter 1

Year: 2021

Type: review

Abstract: The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2021.628705

Authors: Shiwei Zhou, Sujuan Zeng, Yan Shu

Institutions: University of Maryland, Baltimore, Second Xiangya Hospital of Central South University, Guangzhou Medical University

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950