Work

A Luminex based serological assay for detecting IgM and IgG antibody response in SARS-CoV2 patients

Year: 2020

Type: preprint

Abstract: Nucleic acid real-time PCR test has become the main diagnostic tool for SARS‐CoV‐2 infection, and there are also drawbacks to these real-time PCR test kits. Additionally, it has reported high false-negative rates. A reliable and rapid test method is urgently required to briskly detect antibody response in a large number of infected patients and ensure prompt care for patients. Therefore, we report here a Luminex bead based multiplexed immunoassay to serologically diagnose the SARS-CoV2 infection and detect IgM and IgG response in COVID-19 patients. The technology can provide sensitive and specific detection using a low amount of serum samples in high-throughput screening platforms.

DOI: 10.22541/au.159294169.97530983

Authors: Shailendra Mani, Tripti Shrivastava, Sankar Bhattacharyya, Nagender Rameshwaram, Sweety Samal, Sandeep Goswami, Ashok Kumar, Ramandeep Singh, Niraj Kumar, Nitya Wadhwa, Uma Chandra Natchu, Ramachandran Thiruvengadam, Shailaja Sopory, Pallavi Kshetrapal, Bapu Desiraju, Vandita Bhartia

Institution: Translational Health Science and Technology Institute

Language: English

Topic: SARS-CoV-2 detection and testing

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W3132060031

Cites: 4

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Related to: 10