“The Heidelberg Five” personality dimensions: Genome‐wide associations, polygenic risk for neuroticism, and psychopathology 20 years after assessment
Year: 2021
Type: article
Study design: Observational Study
Abstract: ABSTRACT The HeiDE study (‘‘Heidelberger Langzeitstudie zu Risikofaktoren und Diagnose chronischer Erkrankungen’’) is a longitudinal population-based study that started in the 1990s and, at baseline, assessed an array of health-related personality questionnaires in 5 133 individuals. Five latent personality dimensions (The Heidelberg Five) were identified and interpreted as Emotional Lability (ELAB), Lack of Behavioral Control (LBCN), Type A Behavior (TYAB), Locus of Control over Disease (LOCC), and Psychoticism (PSYC). A subset of participants (n=3 268; after quality control) were genotyped on whole-genome arrays at follow-up. To further characterize The Heidelberg Five, we analyzed genomic underpinnings, their relations to the genetic basis of the Big Five trait Neuroticism, and longitudinal associations with lifetime psychiatric symptoms. SNP-based heritability was significant for ELAB (34%) and LBCN (29%). Five separate genome-wide association studies (GWAS) using factor scores on personality dimensions as phenotypes were conducted, only the phenotype PSYC yielded a genome-wide significant finding ( p <5×10 −8 , top SNP rs138223660). Gene-based analyses identified significant findings for ELAB ( Integrin Subunit Beta 5 ), TYAB ( Coiled-coil Domain Containing 83 ), and PSYC ( Nuclear Receptor Subfamily 1 Group H Member 4 ). Polygenic risk scores for Neuroticism, phenotypically related to ELAB, were associated with ELAB, but not with the remaining Heidelberg Five. Longitudinally, all personality dimensions were related to depressive symptoms at follow-up, with ELAB, LBCN, and PSYC also associated with lifetime anxiety symptoms. These results highlight the clinical importance of health-related personality traits, and identify LBCN as a heritable “executive function” personality trait.
DOI: 10.1002/ajmg.b.32837
Authors: Urs Heilbronner, Sergi Papiol, Monika Budde, Till F. M. Andlauer, Jana Strohmaier, Fabian Streit, Josef Frank, Franziska Degenhardt, Stefanie Heilmann‐Heimbach, Stephanie H. Witt, Andreas J. Forstner, Adrian Loerbroks, Manfred Amelang, Til Stürmer, Bertram Müller‐Myhsok, Markus M. Nöthen, Marcella Rietschel, Thomas G. Schulze
Institutions: LMU Klinikum, Institut für Psychiatrische Phänomik und Genomik, Ludwig-Maximilians-Universität München, TUM Klinikum, Technical University of Munich, Heidelberg University, Central Institute of Mental Health, Medizinische Fakultät Mannheim, University of Bonn, University Hospital Bonn, Essen University Hospital, University of Duisburg-Essen, Philipps University of Marburg, University of Basel, Heinrich Heine University Düsseldorf, University of North Carolina at Chapel Hill, Max Planck Institute of Psychiatry, Upstate University Hospital
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Funders: European Commission, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Rheinische Friedrich-Wilhelms-Universität Bonn, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Minority Health and Health Disparities
Awards: G1387591517, Methods for Estimating Sex Differences in Safety and Effectiveness of Drugs, G1527371574, G178062414, G1890467901, G1952140115, G214923873, IntegraMent: Integrierte Untersuchungen von Ursachen und Mechanismen psychiatrischer Störungen, Teilprojekte SP2, SP5, Anteil München, G2725885858, G3341667184, G3374514668, G36025213, G3879576984, G434337789, Racial Differences in Treatment with Hysterectomy: a Multilevel Investigation, G4950536974, Verbundprojekt: IntegraMent: Integrierte Untersuchungen von Ursachen und Mechanismen psychiatrischer Störungen, Teilprojekte TP2, 4, 5 und 10, G5273949324, SYNSCHIZ - Untersuchung synaptischer Dysfunktion als Risikomechanismus der Schizophrenie, DIFUTURE - Medizininformatik-Konsortium - Beitrag Klinikum der TU München, North Carolina Translational and Clinical Science Institute (NC TraCS), G6733821374, Verbundprojekt: IntegraMent: Integrierte Untersuchungen von Ursachen und Mechanismen psychiatrischer Erkrankungen, Teilprojekte 3, 9, 11, Verbundprojekt: IntegraMent: Integrierte Untersuchungen von Ursachen und Mechanismen psychiatrischer Störungen, TP 1: Datenintegration und Modelsysteme TP 2: Zentrale Patienten-Verwaltung, EMBED - Wirkung von metabolischem und psychosozialem Stress auf die Anfälligkeit für psychische Störungen - Identifizierung einer epigenetischen Signatur für die Krankheitsreversibilität der Majoren Depression, Verbund BipoLife im Forschungsnetz psychische Erkrankungen- Identifikation von Genen und microRNAs, B3 sowie Biobankplattfomr und Infrastrukturplattform für alle BipoLife-Projekte sowie alle 9 Verbünde (TPP1/NetBiomics)., G844095261, Propensity scores and preventive drug use in the elderly
OpenAlex ID: W3132196184