Work

Downregulation of death receptor 4 is tightly associated with positive response of EGFR mutant lung cancer to EGFR-targeted therapy and improved prognosis

Year: 2021

Type: article

Abstract: Collectively, we suggest that DR4 downregulation is coupled to therapeutic efficacy of EGFR-targeted therapy and predicts improved prognosis, revealing a previously undiscovered connection between EGFR-targeted therapy and DR4 modulation.

Source: Theranostics

DOI: 10.7150/thno.54824

Authors: Shuo Zhang, Zhen Chen, Puyu Shi, Songqing Fan, Yong He, Qiming Wang, Yixiang Li, Suresh S. Ramalingam, Taofeek K. Owonikoko, Shi-Yong Sun

Institutions: Emory University, Winship Cancer Institute, Central South University, Second Xiangya Hospital of Central South University, Xiangya Hospital Central South University, Daping Hospital, Zhengzhou University, Henan Cancer Hospital

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

Funder: National Cancer Institute

Awards: G4696541794, ECOG-ACRIN Thoracic Malignancies Integrated Translational Science Center, Modulation of death receptor 4 in EGFR-targeted cancer therapy

OpenAlex ID: W3132858053

FWCI: 2.685

Cites: 54

Cited by: 33

Related to: 10