Work

Tumor acidity-induced charge-reversal liposomal doxorubicin with enhanced cancer cell uptake and anticancer activity

Year: 2021

Type: article

Abstract: Concerning that the polyethylene glycol surface layer of DOXIL hinders cancer cell uptake, thus leading to low anticancer activity, it is of great importance to promote the cancer cell uptake of liposomal doxorubicin. Herein, we developed the charge-reversal PEGylated liposomal doxorubicin CRDOXIL with enhanced cancer cell uptake and high anticancer activity. Based on the tumor acidity-induced charge-reversal property, the cancer cell uptake of CRDOXIL could be significantly enhanced and the efficient caveolae-mediated endocytosis was achieved. Moreover, CRDOXIL maintained its stable PEGylated structure in neutral normal physiological environment, thus decreasing the side effects of doxorubicin on normal cells. Therefore, CRDOXIL exhibits high anticancer activity to cancer cells and low cytotoxicity against normal cells. It is anticipated that the charge-reversal strategy could be applied in diverse drug delivery systems to meet the requirement in chemotherapy.

Source: Giant

DOI: 10.1016/j.giant.2021.100052

Authors: Jinpeng Yang, Zihe Yin, Yincheng Chang, Hua Wang, Jiang-Fei Xu, Xi Zhang

Institutions: Tsinghua University, Beijing University of Chemical Technology

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000