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Effect of Body Weight and Age on the Pharmacokinetics of Dihydroartemisinin: Food and Drug Administration Basis for Dose Determination of Artesunate for Injection in Pediatric Patients With Severe Malaria

Year: 2021
Type: article
Abstract: For treatment of severe malaria, the World Health Organization recommends 3 mg/kg intravenous artesunate in pediatric patients weighing less than 20 kg. Here we describe the Food and Drug Administration's rationale for selecting 2.4 mg/kg in pediatric patients weighing less than 20 kg based on literature review and independent analyses.
DOI: 10.1093/cid/ciab149
Authors: Eliford Kitabi, Timothy J Bensman, Justin C Earp, Dakshina M Chilukuri, Heidi Smith, Leslie Ball, Elizabeth O’Shaughnessy, Yuliya Yasinskaya, Philip M Colangelo, Kellie S Reynolds
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,052
OpenAlex ID: W3133022102
FWCI: 1.73
Cites: 14
Cited by: 9
Related to: 10