Work

Revealing the Physiological Origin of Event-Related Potentials using Electrocorticography in Humans

Year: 2021

Type: preprint

Abstract: The scientific and clinical value of event-related potentials (ERPs) depends on understanding the contributions to them of three possible mechanisms: (1) additivity of time-locked voltage changes; (2) phase resetting of ongoing oscillations; (3) asymmetrical oscillatory activity. Their relative contributions are currently uncertain. This study uses analysis of human electrocorticographic activity to quantify the origins of movement-related potentials (MRPs) and auditory evoked potentials (AEPs). The results show that MRPs are generated primarily by endogenous additivity (88%). In contrast, P1 and N1 components of AEPs are generated almost entirely by exogenous phase reset (93%). Oscillatory asymmetry contributes very little. By clarifying ERP mechanisms, these results enable creation of ERP models; and they enhance the value of ERPs for understanding the genesis of normal and abnormal auditory or sensorimotor behaviors.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2021.02.12.430921

Authors: Hohyun Cho, Gerwin Schalk, Markus Adamek, Ladan Moheimanian, William G. Coon, Sung Chan Jun, Jonathan R. Wolpaw, Peter Brunner

Institutions: Washington University in St. Louis, Albany Medical College, State University of New York, University at Albany, State University of New York, Johns Hopkins University, Johns Hopkins University Applied Physics Laboratory, Gwangju Institute of Science and Technology

Language: English

Topic: Neural dynamics and brain function

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Institute for Information and Communications Technology Promotion, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, Army Research Office

Awards: G2156757918, G2218054138, G3424441068, G3622582212, G5549936139, G5890768851, Dynamics and Causal Functions of Large-Scale Cortical and Subcortical Networks, BCI2000+: A Software Platform for Adaptive Neurotechnologies, G7452299184, G801315950, BCI2000: Software Resource for Adaptive Neurotechnology Research, Center for Adaptive Neurotechnologies, G8933936870, G9000066060, G9000096072, Neurobiology and Cognitive Role of Slow Brain Network Fluctuations

OpenAlex ID: W3133024100

Cites: 79

Cited by: 4

Related to: 10