Sex Differences in the Effects of Osteocalcin and Exercise on Cognition and Behaviour in a High-fat Diet Model of Type 2 Diabetes
Year: 2020
Type: dissertation
Abstract: Osteocalcin is a protein produced in bone and found both in the bone matrix and circulation. Mouse studies have demonstrated anti-diabetic and anti-aging effects of osteocalcin. Osteocalcin research in mice has almost exclusively been conducted in only one sex and could not account for sex as a biological variable. We hypothesized that osteocalcin and exercise would improve behavioural outcomes and aimed to record any difference in response between sexes. We compared the effects of diet, exercise, osteocalcin treatment, or the combination of both, in male and female mice on a high-fat diet-induced model of type 2 diabetes. Osteocalcin decreased depressive-like behaviours and improved problem-solving in both sexes, and exercise decreased depression in both sexes. The effects of osteocalcin were similar in male and female mice; however, exercise increased anxiety-like behaviours only in males and improved problem-solving only in females. Osteocalcin and exercise affected behaviour similarly but not identically.
Source: TSpace (University of Toronto)
Author: Jordan Winberg
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3133034925