Work

14-Year Changes in Plasma Neurofilament Levels Among Men: A Pilot Study

Year: 2021

Type: article

Abstract: Little is known about the feasibility of using long-term stored blood samples to measure neurofilament levels and about long-term changes in neurofilament levels among healthy individuals. We performed a pilot study among 26 adult men in preparation for a larger-scale study of the natural history of neurofilament levels. Median change over 14 years in pNf-H was 97.1 pg/mL (IQR: 5.0 to 242.0 pg/mL) and in Nf-L was 2.117 pg/mL (IQR: -2.691 to 3.393 pg/mL). We demonstrated the feasibility of measuring neurofilament concentrations in stored blood samples and found a trend between age and increases in Nf-L levels among adults.

Source: Journal of Neuromuscular Diseases

DOI: 10.3233/jnd-200623

Authors: Pamela M. Rist, Varant Kupelian, Marco Petrillo, Jihee Sohn, Wildon Farwell, Howard D. Sesso

Institutions: Brigham and Women's Hospital, Harvard University, Biogen (United States)

Language: English

Topic: Skin and Cellular Biology Research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute