Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave
Year: 2021
Type: article
Abstract: Microglia, the brain's resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor (CSF1Ri) approach, we report an unprecedented level of microglial depletion and establish a model system that achieves an empty microglial niche in the adult brain. We identify a myeloid cell that migrates from the subventricular zone and associated white matter areas. Following CSF1Ri, these amoeboid cells migrate radially and tangentially in a dynamic wave filling the brain in a distinct pattern, to replace the microglial-depleted brain. These repopulating cells are enriched in disease-associated microglia genes and exhibit similar phenotypic and transcriptional profiles to white-matter-associated microglia. Our findings shed light on the overlapping and distinct functional complexity and diversity of myeloid cells of the CNS and provide new insight into repopulating microglia function and dynamics in the mouse brain.
Source: eLife
DOI: 10.7554/elife.66738
Institution: University of California, Irvine
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,500
Awards: G1010341072, G1053905225, G1234896216, G228888080, G3586461574, G3661413091, Manipulating microglia to prevent Alzheimer's disease, Microglia are necessary for cortical plaque formation in Alzheimer's disease, G9000024008, G9000063855, G9000082705, Origins, properties, and therapeutic potential of cells that repopulate the microglia-depleted adult brain, G964936421
OpenAlex ID: W3195546197