Year: 2021
Type: article
Study design: Observational Study
Abstract: Respiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known about the host immune response to RV infection in PWH. Here, we investigated gene expression changes in the peripheral blood of PWH co-infected with RV. Only very few differentially expressed genes could be detected between PWH with and without RV infection, suggesting that the immune response to RV in PWH is strongly dampened. Our data provides important insights into the host response to RV infections in HIV patients.
Source: Scientific Reports
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,990
Funders: University of Memphis, Helmholtz-Gemeinschaft, Health Science Center, University of Tennessee, Medical Research Council, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Environmental Health Sciences, Center for AIDS Research, University of North Carolina at Chapel Hill, School of Medicine, University of North Carolina at Chapel Hill
OpenAlex ID: W3133347437