Work

Rationally Programming Nanomaterials with DNA for Biomedical Applications

Year: 2021

Type: review

Abstract: DNA is not only a carrier of genetic information, but also a versatile structural tool for the engineering and self-assembling of nanostructures. In this regard, the DNA template has dramatically enhanced the scalability, programmability, and functionality of the self-assembled DNA nanostructures. These capabilities provide opportunities for a wide range of biomedical applications in biosensing, bioimaging, drug delivery, and disease therapy. In this review, the importance and advantages of DNA for programming and fabricating of DNA nanostructures are first highlighted. The recent progress in design and construction of DNA nanostructures are then summarized, including DNA conjugated nanoparticle systems, DNA-based clusters and extended organizations, and DNA origami-templated assemblies. An overview on biomedical applications of the self-assembled DNA nanostructures is provided. Finally, the conclusion and perspectives on the self-assembled DNA nanostructures are presented.

Source: Advanced Science

DOI: 10.1002/advs.202003775

Authors: Liangcan He, Jing Mu, Oleg Gang, Xiaoyuan Chen

Institutions: National University of Singapore, Peking University Shenzhen Hospital, Brookhaven National Laboratory, Center for Functional Nanomaterials, Columbia University

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,000

Funders: National Science Foundation, U.S. Department of Energy, National University of Singapore, National Natural Science Foundation of China