Tumor contrast enhancement using fluorescence lifetime: a new promise for image guided surgery (Conference Presentation) (Withdrawal Notice)
Year: 2021
Type: conference-paper
Abstract: Despite improving survival rates, a major challenge for oncologic surgery is the accurate identification of tumor-positive margins both intraoperatively and in resection specimens immediately following surgery. Fluorescence intensity-based imaging, using tumor specific near infrared fluorescent agents is currently being evaluated for tumor margin assessment, but suffers from large background signals due to tissue autofluorescence and non-specific probe uptake in healthy tissue, significantly reducing sensitivity and specificity. Here we present preclinical and clinical data to demonstrate that fluorescence lifetime measurements using exogenous near infrared probes can significantly improve the accuracy for tumor vs. normal classification in the presence of non-specific background fluorescence.
DOI: 10.1117/12.2576446
Institution: Massachusetts General Hospital
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W3133558418