Year: 2021
Type: article
Abstract: The polyamine spermidine is essential for protein translation in eukaryotes, both as a substrate for the hypusination of the translation initiation factor eIF5A as well as general translational fidelity. Dwindling spermidine levels during aging have been implicated in reduced immune cell function through insufficient eIF5A hypusination, which can be restored by external supplementation. Recent findings characterize a group of novel Mendelian disorders linked to EIF5A missense and nonsense variants that cause protein translation defects. In model organisms that recapitulate these mutations, spermidine supplementation was able to alleviate at least some of the concomitant protein translation defects. Here, we discuss the role of spermidine in protein translation and possible therapeutic avenues for translation-associated disorders.
Source: Cell Stress
Institutions: University of Graz, Nawi Graz, BioTechMed-Graz
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,283
Funders: National Centre for the Replacement, Refinement and Reduction of Animals in Research, Austrian Science Fund, Bundesministerium für Wissenschaft, Forschung und Wirtschaft, Karl-Franzens-Universität Graz, Bundesministerium für Bildung, Wissenschaft und Forschung, BioTechMed-Graz, Biotechnology and Biological Sciences Research Council
Awards: G2086690636, Geroprotection By Synergistic Anti-Aging Interventions, G2660494300, G3366334949, G3437918550, Pro-autophagic polyphenols and polyamines for longevity, G3880385263, G4587442245, Causal epigenetic changes during aging and caloric restriction, G6353865127, G6453302570, G6828301905, Metabolic and Cardiovascular Disease, G7914284967, Mechanisms of spermidine mediated neuroprotection, G98648609
OpenAlex ID: W3133580776