The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
Year: 2021
Type: article
Abstract: The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.
Source: Life Science Alliance
Authors: Mariano F Zacarías-Fluck, Toni Jauset, Sandra Martínez-Martín, Jastrinjan Kaur, Sílvia Casacuberta-Serra, Daniel Massó-Vallés, Erika Serrano del Pozo, Génesis Martín-Fernández, Íñigo González-Larreategui, Sergio López-Estévez, Lamorna Brown-Swigart, Marie-Eve Beaulieu, Jonathan R Whitfield, Babita Madan, David M Virshup, Gerard I Evan, Laura Soucek
Institutions: Vall d'Hebron Hospital Universitari, Vall d'Hebron Institute of Oncology, University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, National University of Singapore, Duke-NUS Medical School, University of Cambridge, Institució Catalana de Recerca i Estudis Avançats, Universitat Autònoma de Barcelona
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,500
Awards: G2817595060, G3882942521, G4999529193
OpenAlex ID: W3133700221