Work

Analysis of intensity correlation enhanced plasmonic structured illumination microscopy

Year: 2021

Type: article

Abstract: We propose to enhance the performance of localized plasmon structured illumination microscopy (LP-SIM) via intensity correlations. LP-SIM uses sub-wavelength illumination patterns to encode high spatial frequency information. It can enhance the resolution up to three-fold before gaps in the optical transfer function (OTF) support arise. For blinking fluorophores or for quantum antibunching, an intensity correlation analysis induces higher harmonics of the illumination pattern and enlarges the effective OTF. This enables ultrahigh resolutions without gaps in the OTF support, and thus a fully deterministic imaging scheme. We present simulations that include shot and external noise and demonstrate the resolution power under realistic photon budgets. The technique has potential in light microscopy where low-intensity illumination is paramount while aiming for high spatial but moderate temporal resolutions.

Source: Optics Letters

DOI: 10.1364/ol.418292

Authors: Anton Classen, Xinghua Liu, Aleksei M. Zheltikov, Girish S. Agarwal

Institutions: Texas A&M University, Lomonosov Moscow State University, Kazan State Technical University named after A. N. Tupolev, Russian Quantum Center

Language: English

Topic: Advanced Fluorescence Microscopy Techniques

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Welch Foundation, Russian Foundation for Basic Research, Russian Science Foundation, Ministry of Science and Higher Education of the Russian Federation