Work

Respiratory effects of low and high doses of fentanyl in control and β-arrestin 2-deficient mice

Year: 2021

Type: article

Abstract: When life-threatening doses of fentanyl are used in mice, the β-arrestin 2 pathway appears to play a critical role in the recovery from opioid overdose. This observation calls into question the use of G protein-biased μ-opioid receptor agonists, as a strategy for safer opioid analgesic drugs.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00711.2020

Authors: Philippe Haouzi, Marissa McCann, Nicole Tubbs

Institution: Pennsylvania State University

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute