Work

Disparate roles of retinoid acid signaling molecules in kidney disease

Year: 2021

Type: article

Abstract: Retinoic acid (RA) exerts pleotropic cellular effects, including induction of cell differentiation while inhibiting proliferation and inflammation. These effects are mediated by both RA responsive element-dependent or -independent pathways. In kidneys, RA confers renoprotection by signaling through podocyte RA receptor (RAR)α and activation of cAMP/PKA/Kruppel-like factor 15 pathway to promote podocyte differentiation. Nevertheless, in kidney disease settings, RA can also promote podocyte apoptosis and loss through downstream expression of RAR responder protein 1, a recently described risk factor for glomerular disease progression. These disparate roles of RA underscore the complexity of its effects in kidney homeostasis and disease, and a need to target specific RA-mediated pathways for effective therapeutic treatments against kidney disease progression.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00045.2021

Authors: Anqun Chen, Yu Liu, Yu Lu, Kyung Lee, John Cijiang He

Institutions: Central South University, Second Xiangya Hospital of Central South University, Boston University, Icahn School of Medicine at Mount Sinai, James J. Peters VA Medical Center

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Natural Science Foundation of China, National Institute of Diabetes and Digestive and Kidney Diseases