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In-vivo optical microscopy and single cell transcriptomics approaches provide insights into therapeutic response of vitiligo

Year: 2021

Type: conference-paper

Abstract: Vitiligo is an immune skin disorder consisting of depigmented skin patches caused by the destruction of epidermal melanocytes. Vitiligo treatment represents a clinical challenge since the re-pigmentation mechanism is not fully understood. In this pilot study, we employ in-vivo multiphoton microscopy to evaluate epidermal keratinocyte metabolic state before and during treatment, in-vivo reflectance confocal microscopy to track melanocyte migration after treatment initiation, and single cell transcriptomics to identify unique cell populations more abundant in stable vitiligo lesions compared to normal skin. The findings provide insights into the role of certain cell populations in the viability of micro-grafting treatments.

Source: Photonics in Dermatology and Plastic Surgery

DOI: 10.1117/12.2582167

Authors: Griffin R. Lentsch, Jessica Shiu, Jessica Flesher, Pezhman Mobasher, Christopher Polleys, Craig Mizzoni, Karsten König, Suoqin Jin, Lihua Zhang, Bruce J. Tromberg, Qing Nie, Irene Georgakoudi, Anand K. Ganesan, Mihaela Balu

Institutions: Beckman Laser Institute and Medical Clinic, University of California, Irvine, Tufts University, JenLab (Germany), National Institute of Biomedical Imaging and Bioengineering

Language: English

Topic: melanin and skin pigmentation

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3134091273

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