Work

Placenta DNA methylation at ZNF300 is associated with fetal sex and placental morphology

Year: 2021

Type: preprint

Study design: Observational Study

Abstract: Fetal sex-specific differences in placental morphology and physiology have been associated with sexually dimorphic health outcomes. However, the molecular mechanisms underlying these sex differences are not well understood. We performed whole genome bisulfite sequencing in 133 placenta samples and discovered a significant difference in DNA methylation (DNAm) at the ZNF300 gene locus between male and female offspring and replicated this result in 6 independent datasets. Additionally, the sex-specific pattern appears to be placenta-specific, is robust to a wide range of gestational ages and adverse health outcomes and is present in sorted placenta villous cytotrophoblast cells. Integration of DNAm, genetic, and placental morphology data from the same individuals revealed ZNF300 methylation is also associated with placenta area, perimeter, and max diameter, genetic variants on chromosomes 5 and X, and may mediate the effects of genetic variation on placental area.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2021.03.05.433992

Authors: Christine Ladd-Acosta, Shan V. Andrews, Kelly M. Bakulski, Jason I. Feinberg, Rakel Tryggvadottir, Ruofan Yao, Lisa A. Croen, Irva Hertz-Picciotto, Craig J. Newschaffer, Carolyn M. Salafia, Andrew P. Feinberg, Kasper D. Hansen, M. Daniele Fallin

Institutions: Johns Hopkins University, University of Michigan, Johns Hopkins Medicine, Loma Linda University Medical Center, Loma Linda University, Kaiser Permanente, Kaiser Permanente Northern California, University of California, Davis, Pennsylvania State University, Drexel University

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Autism Speaks, University of Pennsylvania, Colorado Department of Public Health and Environment, Michigan State University, Johns Hopkins University, Wellcome Trust, National Institutes of Health, Centers for Disease Control and Prevention, College of Engineering, Michigan State University, Kaiser Foundation Research Institute, University of North Carolina at Chapel Hill, National Institute of Environmental Health Sciences

Awards: G1005776355, G1073156504, G1325382752, G1589704429, G1693035172, G1695356537, G1698090921, G1799356628, G2112919472, G2201851652, G2769056299, G2922796427, G3013325417, G3199248096, G348543287, G3507101531, G4000839584, NORTH CAROLINA CTR FOR AUTISM & DEVELOPMENT DISABILITIES RESEARCH & EPIDEMIOLOGY, G4412438158, G455390876, G4675448330, G4689219259, G4841778848, NATIONAL CADDRE STUDY: CHILD DEVELOPMENT AND AUTISM, G505094182, G5190902592, G5250426371, NATIONAL CADDRE STUDY: CHILD DEVELOPMENT AND AUTISM, G5471001079, G5705284310, G5885571094, CENTERS FOR AUTISM & DEVELOP DISABILITIES RESARCH & EPIDEMIOL:A CASE-COHORT STUDY, COLORADO CADDRE: A CASE-COHORT STUDY, G6600914918, G664877711, G6838829540, G698974336, Environment, The Perinatal Epigenome, and Risk for Autism and Related Disorders, G7018679994, Early Autism Risk Longitudinal Investigation (EARLI) Network, G746684721, G7480918048, G7621443489, G7741351181, G7989798703, G8562569119, G8572334971, G8604585336, G8638173091, G8857404556

OpenAlex ID: W3134468884

Cites: 98

Cited by: 6

Related to: 10