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A longitudinal resource for studying connectome development and its psychiatric associations during childhood

Year: 2022
Type: data-paper
Abstract: Most psychiatric disorders are chronic, associated with high levels of disability and distress, and present during pediatric development. Scientific innovation increasingly allows researchers to probe brain-behavior relationships in the developing human. As a result, ambitions to (1) establish normative pediatric brain development trajectories akin to growth curves, (2) characterize reliable metrics for distinguishing illness, and (3) develop clinically useful tools to assist in the diagnosis and management of mental health and learning disorders have gained significant momentum. To this end, the NKI-Rockland Sample initiative was created to probe lifespan development as a large-scale multimodal dataset. The NKI-Rockland Sample Longitudinal Discovery of Brain Development Trajectories substudy (N = 369) is a 24- to 30-month multi-cohort longitudinal pediatric investigation (ages 6.0-17.0 at enrollment) carried out in a community-ascertained sample. Data include psychiatric diagnostic, medical, behavioral, and cognitive phenotyping, as well as multimodal brain imaging (resting fMRI, diffusion MRI, morphometric MRI, arterial spin labeling), genetics, and actigraphy. Herein, we present the rationale, design, and implementation of the Longitudinal Discovery of Brain Development Trajectories protocol.
DOI: 10.1038/s41597-022-01329-y
Authors: Russell H. Tobe, Anna MacKay-Brandt, Ryan Lim, Melissa Kramer, Melissa M. Breland, Lucia Tu, Yiwen Tian, Kristin Dietz Trautman, Caixia Hu, Raj Sangoi, Lindsay Alexander, Vilma Gabbay, F. Xavier Castellanos, Bennett L. Leventhal, R. Cameron Craddock, Stanley J. Colcombe, Alexandre R. Franco, Michael P. Milham
Institutions: Nathan Kline Institute for Psychiatric Research, Columbia University Irving Medical Center, Child Mind Institute, Albert Einstein College of Medicine, New York University, University of Chicago, The University of Texas at Austin
Language: English
Open Access status: gold
Estimated APC paid: $2,090
Funders: U.S. Department of Health and Human Services, New York State Office of Mental Health, Child Mind Institute, National Institutes of Health, National Institute on Aging, National Institute of Mental Health
Awards: G1021585888, Mapping interindividual variation in the aging connectome, G2951394183, G3075147305, Biobehavioral Predictors of Illness Progression in Adolescent Depression, Discovery Science of Human Brain Function Across the Lifespan, G417619881, G4243980428, Real-time fMRI Neurofeedback Based Stratification of Default Network Regulation, G6775002179, Longitudinal Discovery of Brain Developmental Trajectories, G6930348172, G8273361195
OpenAlex ID: W4282842143
Cites: 122
Cited by: 47
Related to: 10