Podocyte Lipotoxicity in CKD
Year: 2021
Type: article
Abstract: CKD represents the ninth most common cause of death in the United States but, despite this large health burden, treatment options for affected patients remain limited. To remedy this, several relevant pathways have been identified that may lead to novel therapeutic options. Among them, altered renal lipid metabolism, first described in 1982, has been recognized as a common pathway in clinical and experimental CKD of both metabolic and nonmetabolic origin. This observation has led many researchers to investigate the cause of this renal parenchyma lipid accumulation and its downstream effect on renal structure and function. Among key cellular components of the kidney parenchyma, podocytes are terminally differentiated cells that cannot be easily replaced when lost. Clinical and experimental evidence supports a role of reduced podocyte number in the progression of CKD. Given the importance of the podocytes in the maintenance of the glomerular filtration barrier and the accumulation of TG and cholesterol-rich lipid droplets in the podocyte and glomerulus in kidney diseases that cause CKD, understanding the upstream cause and downstream consequences of lipid accumulation in podocytes may lead to novel therapeutic opportunities. In this review, we hope to consolidate our understanding of the causes and consequences of dysregulated renal lipid metabolism in CKD development and progression, with a major focus on podocytes.
Source: Kidney360
Authors: Jin-Ju Kim, Sydney S. Wilbon, Alessia Fornoni
Institution: University of Miami
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: F. Hoffmann-La Roche, Alport Syndrome Foundation, National Institutes of Health, Miami Clinical and Translational Science Institute, University of Miami, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: G1023762287, G195356861, G242051987, G3258811144, University of Michigan O'Brien Kidney Translational Core Center, G4034409254, The role of DDR1 in podocyte lipotoxicity and progression of Alport Syndrome, SMPDL3b and podocyte insulin signaling in DKD, G6080841962, Miami Clinical and Translational Science Institute, G7241994140, George M. O'Brien Kidney Center at Yale, 1-13 ApoL1 Genotypes in Kidney Donors and Long-Term Outcomes in Kidney Transplant Recipients Clinical Center
OpenAlex ID: W3134597442