Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-II and its Mechanism of signal transmission in vitro
Year: 2021
Type: article
Abstract: COVID-19 cases showed a significant decrease in the number of peripheral CD4 + and CD8 + T cells accompanied by overactivation of cells. 1 HHV8-derived viral macrophage inflammatory protein vMIP-II is the only broad-spectrum chemokine receptor inhibitor that binds to three subtribes of chemokine receptors, which can significantly increase the specific cell immune response in infected organisms and have an effect of reducing plasma viral load on the viremia period. 2 , 3 , 4 Here we report the effect of vMIP-II in COVID-19.
Authors: Shiyu Li, Shuting Liu, Zhenyou Jiang, Lixia Feng, Yong Gao, Youyu Chen, Anding Xu, Wenhua Huang, Nuofu Zhang, Hanxiao Sun
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,775
Awards: G2236851206, G8144639179
OpenAlex ID: W3134633322