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Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

Year: 2021
Type: article
Abstract: TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b-/- mouse model. By using high-power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss.
DOI: 10.1111/bpa.12945
Authors: Rosa Rademakers, Alexandra M. Nicholson, Yingxue Ren, Shunsuke Koga, Hung Phuoc Nguyen, Mieu Brooks, Wenhui Qiao, Zachary S. Quicksall, Billie Matchett, Ralph B. Perkerson, Aishe Kurti, Monica Castanedes‐Casey, Virginia Phillips, Ariston L Librero, Cristhoper H. Fernandez De Castro, Matthew C. Baker, Shanu F. Roemer, Melissa E. Murray, Yan Asmann, John D. Fryer, Guojun Bu, Dennis W. Dickson, Xiaolai Zhou
Institutions: Mayo Clinic, University of Antwerp, VIB-UAntwerp Center for Molecular Neurology, Mayo Clinic in Florida, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Language: English
Open Access status: gold
Estimated APC paid: $3,500
OpenAlex ID: W3134724681
FWCI: 1.076
Cites: 10
Cited by: 16
Related to: 10