Work

Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids

Year: 2021

Type: article

Abstract: -amino acids can be obtained using this method. Mechanistic studies are consistent with the aminomethylation to proceed via silylium-based asymmetric counteranion-directed catalysis (Si-ACDC) and a transition state to explain the enantioselectivity is suggested on the basis of density functional theory calculation.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.1c00249

Authors: Chendan Zhu, Francesca Mandrelli, Hui Zhou, Rajat Maji, Benjamin List

Institution: Max-Planck-Institut für Kohlenforschung

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,000

Funders: Deutsche Forschungsgemeinschaft, H2020 European Research Council