Year: 2021
Type: article
Abstract: PsilocybinPsilocybin, derived from mushrooms belonging to the genus Psilocybe, and psilocin, its active metabolite, are indolamines.Recent studies have shown that psilocybin has effects on brain functional connectivity.14 Its effects include reducing negative affect and amygdala response to emotional faces at 1 week, with enduring changes in resting state functional connectivity (RSFC) at 1 month, 15 along with reducing activity in the default mode network (DMN) (including the subgenual cingulate cortex) in healthy individuals 16 and causing changes in synaptic plasticity.13 Contrary to the finding in healthy individuals, psilocybin was associated with increased resting state connectivity within the DMN between the ventromedial prefrontal cortex and the bilateral inferior-lateral parietal cortex after 2 psilocybin treatments in treatment-resistant depression patients and was predictive of clinical response 5 weeks posttreatment.17
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: bronze
OpenAlex ID: W3135419810