Work

Decellularized xenografts in regenerative medicine: From processing to clinical application

Year: 2021

Type: review

Abstract: Decellularized xenografts are an inherent component of regenerative medicine. Their preserved structure, mechanical integrity and biofunctional composition have well established them in reparative medicine for a diverse range of clinical indications. Nonetheless, their performance is highly influenced by their source (ie species, age, tissue) and processing (ie decellularization, crosslinking, sterilization and preservation), which govern their final characteristics and determine their success or failure for a specific clinical target. In this review, we provide an overview of the different sources and processing methods used in decellularized xenografts fabrication and discuss their effect on the clinical performance of commercially available decellularized xenografts.

Source: Xenotransplantation

DOI: 10.1111/xen.12683

Authors: Héctor Capella‐Monsonís, Dimitrios I. Zeugolis

Institutions: Science Foundation Ireland, Ollscoil na Gaillimhe – University of Galway, Università della Svizzera italiana

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,700