Estimating the reproducibility of psychotherapy effects in mood and anxiety disorders: the possible utility of multicenter trials
Year: 2021
Type: article
Abstract: ed submission on prior registration, prospective registration is implemented in only 40% of trials of psychotherapies for depression.Among prospectively registered trials, 25% displayed discrepancies between registration and publications, and for 17% we judged these discrepancies as favoring statistical significance.Though relatively few, trials with selective reporting were associated with considerably larger effectiveness, when combined in a meta-analysis.Effect sizes diverged by a SMD of 0.27 between trials with and without selective reporting.For reference, selective publication of trials of psychotherapies for depression has been associated with differences in effectiveness of 0.32 7 .Trials with non-reporting of registered outcomes or addition of non-registered ones emerged as the main drivers of effect size inflation.These data suggest that lack of prior registration and discrepancies between registration and publications remain common in trials of psychotherapies for depression, and are associated with an inflation of effect sizes in those trials, contributing to the current uncertainties in assessing the outcomes of psychological interventions 8,9 .
Source: World Psychiatry
DOI: 10.1002/wps.20901
Authors: Christoph Flückiger, Jessica Paul, Peter Hilpert, Andreea Vîslă, Juan‐Martin Gómez Penedo, Greta Helene Probst, Bruce E. Wampold
Language: English
Subfield: Statistics, Probability and Uncertainty
Field: Decision Sciences
Domain: Social Sciences
Open Access status: hybrid
OpenAlex ID: W3135513633