Work

A new synthetic protectin D1 analog 3-oxa-PD1 n-3 DPA reduces neuropathic pain and chronic itch in mice

Year: 2021

Type: article

Abstract: The novel protectin D1 analog 3-oxa-PD1 n-3 DPA was synthesized. Nanogram amounts of this analog reduces neuropathic pain and chronic itch, and shows analgesic action in a mouse model of diabetic neuropathy.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d0ob02136a

Authors: Jannicke Irina Nesman, Ouyang Chen, Xin Luo, Ru-Rong Ji, Charles N. Serhan, Trond Vidar Hansen

Institutions: University of Oslo, Duke Medical Center, Brigham and Women's Hospital, Harvard University

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Duke University, Norges Forskningsråd, National Institutes of Health, National Institute of General Medical Sciences

Awards: G3752863721, G388467162, Blood Cell Lipoxygenase Products -- Formation and Action

OpenAlex ID: W3135548236

FWCI: 2.752

Cites: 69

Cited by: 27

Related to: 10