Work

Conformational fingerprinting of tau variants and strains by Raman spectroscopy

Year: 2021

Type: article

Abstract: We report that the physiochemical properties of the aggregation environment dictate the conformation of tau strains, which can be characterized and distinguished using Raman spectroscopy.

Source: RSC Advances

DOI: 10.1039/d1ra00870f

Authors: George Devitt, Anna Crisford, William Rice, Hilary A. Weismiller, Zhanyun Fan, Caitlin Commins, Bradley T. Hyman, Martin Margittai, Sumeet Mahajan, Amrit Mudher

Institutions: University of Southampton, University of Denver, Harvard University, Massachusetts General Hospital

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: Rosetrees Trust, National Institutes of Health, Engineering and Physical Sciences Research Council, National Institute on Aging, H2020 European Research Council

Awards: G1215197137, Liquid liquid phase separation and tau biology, Next Generation Label-free Chemical Nanoscopy for Biomedical Applications, G6360596856, Complexity and Heterogeneity of Alzheimer disease, Tau pathology in Down syndrome and Alzheimer's, Lighting the Way to a Healthy Nation - Optical 'X-rays' for Walk Through Diagnosis & Therapy, Are multiple tau species toxic in Alzheimer's Disease?, Massachusetts Alzheimer's Disease Research Center (MADRC)

OpenAlex ID: W3135756013

FWCI: 3.923

Cites: 89

Cited by: 37

Related to: 10