Targetable pathogenic mechanisms in nasal polyposis
Year: 2021
Type: review
Abstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) represents a challenging disease entity with significant rates of recurrence following appropriate medical and surgical therapy. Recent approval of targeted biologics in CRSwNP compels deeper understanding of underlying disease pathophysiology. Both of the approved biologics for CRSwNP modulate the type 2 inflammatory pathway, and the majority of drugs in the clinical trials pathway are similarly targeted. However, there remain multiple other pathogenic mechanisms relevant to CRSwNP for which targeted therapeutics already exist in other inflammatory diseases that have not been studied directly. In this article we summarize pathogenic mechanisms of interest in CRSwNP and discuss the results of ongoing clinical studies of targeted therapeutics in CRSwNP and other related human inflammatory diseases.
DOI: 10.1002/alr.22787
Institution: Northwestern University
Language: English
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Type-2 inflammation mediates olfactory loss in Chronic Rhinosinusitis: mechanisms and therapeutic opportunities, Chronic Rhinosinusitis Integrative Studies Program 2 (CRISP2), Northwestern University Clinical and Translational Science Institute (NUCATS), G5609351756, Initiators, biomarkers and mechanisms of epithelial dysfunction and immune pathogenesis in chronic rhinosinusitis and aspirin exacerbated respiratory disease (AERD), G7528589968, Autoantibody mediated pathogenesis in chronic rhinosinusitis with nasal polyps: mechanisms and consequences, Northwestern University Allergy and Immunology Research (NUAIR) Program
OpenAlex ID: W3135788996