Work

Taurine Chloramine and Hydrogen Peroxide as a Potential Source of Singlet Oxygen for Topical Application

Year: 2021

Type: article

Abstract: Singlet oxygen ( 1 O 2 ) is the “active principle” in photodynamic therapy. Taurine chloramine (Tau‐NHCl) and hydrogen peroxide (H 2 O 2 ) are well‐tolerated and widely used antiseptics. Due to its mild oxidizing features and stability, Tau‐NHCl can be directly used to treat skin diseases. We found that a diluted aqueous mixture of Tau‐NHCl and H 2 O 2 acts as a slow and long‐lasting potential source of 1 O 2 . The reactions were studied by luminol‐enhanced chemiluminescence. Evidence of the formation of 1 O 2 was obtained using deuterium oxide, sodium azide and 9,10‐Anthracenediyl‐bis(methylene)dimalonic acid, a chemical trap of 1 O 2 . The reaction was optimized, and a mechanism was proposed, including theoretical calculations at B3LYP/6‐311++G(3df,2p) level of theory, adding D3Bj empirical dispersion and SMD (Water) solvent effects. Chloramines produced by the reactions between HOCl and L ‐alanine, 3‐amino‐1‐propanesulfonic acid and gamma‐aminobutyric acid were also prepared, and their reactivity and stability were compared with Tau‐NHCl. We found that Tau‐NHCl is more stable and adequate for the production of 1 O 2 . In conclusion, we propose applying these drugs combination as a potential source of 1 O 2 with applications for skin diseases treatment.

Source: Photochemistry and Photobiology

DOI: 10.1111/php.13410

Authors: Valdecir F. Ximenes, Thomaz P. Ximenes, Nelson H. Morgon, Aguinaldo R. de Souza

Institutions: Universidade Estadual Paulista (Unesp), Universidade Estadual de Campinas (UNICAMP)

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico