Work

Rate Profiling the Impact of Remote Functional Groups on the Redox-Relay Heck Reaction

Year: 2021

Type: article

Abstract: The redox-relay Heck reaction is a powerful method for the construction of enantioenriched quaternary stereocenters remote from existing functional groups. However, there has been little success in the design of site-selective alkene functionalization based on these methods. Herein, we show that experimentally determined rates can be used to train a multivariate linear regression model capable of predicting the rate of a specific relay Heck reaction, allowing for the site-selective functionalization of diene substrates.

Source: Organic Letters

DOI: 10.1021/acs.orglett.1c00450

Authors: Samantha L. Kraus, Sean P. Ross, Matthew S. Sigman

Institution: University of Utah

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Center for Research Resources, Division of Chemistry