Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
Year: 2021
Type: review
Abstract: The proper expression of gonadotropin-releasing hormone receptors (GnRHRs) by pituitary gonadotropes is critical for maintaining maximum reproductive capacity. GnRH receptor expression must be tightly regulated in order to maintain the normal pattern of expression through the estrous cycle in rodents, which is believed to be important for interpreting the finely tuned pulses of GnRH from the hypothalamus. Much work has shown that Gnrhr expression is heavily regulated at the level of transcription. However, researchers have also discovered that Gnrhr is regulated post-transcriptionally. This review will discuss how RNA-binding proteins and microRNAs may play critical roles in the regulation of GnRHR expression. We will also discuss how these post-transcriptional regulators may themselves be affected by metabolic cues, specifically with regards to the adipokine leptin. All together, we present evidence that Gnrhr is regulated post-transcriptionally, and that this concept must be further explored in order to fully understand the complex nature of this receptor.
DOI: 10.3390/ijms22073312
Institution: University of Arkansas for Medical Sciences
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,160
Awards: Post-transcriptional Pathways that Signal Leptin Regulation of Gonadotropes, The Impact of Obesity on Somatotrope Function, G273385131, Control of pituitary cell plasticity through regulated mRNA translation, Center for Translational Neuroscience, The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes, Tropic Roles for Leptin in the Maturation of Somatotropes
OpenAlex ID: W3136120216