Work

Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens

Year: 2021

Type: article

Abstract: Activation of self-reactive CD8+T cells induces a peripheral tolerance mechanism that involves loss of CD8 expression. Because genetic deficiency ofFasandFaslcauses the accumulation of double-negative (DN; CD3+TCR-αβ+CD4-CD8-) T cells that have been proposed to derive from CD8+cells, we decided to explore the role of Fas and FasL in self-antigen-induced CD8 downregulation. To this end, we quantified Fas and FasL induction by different stimuli and analyzed the effects of Fas/FasL deficiency during a protective immune response and after exposure to self-antigens. Our data describes how Fas and FasL upregulation differs depending on the setting of CD8 T cell activation and demonstrates that Fas/FasL signaling maintains CD8 expression during repetitive antigen stimulation and following self-antigen encounter. Together, our results reveal an unexpected role of Fas/FasL signaling and offer a new insight into the role of these molecules in the regulation of immune tolerance.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2021.635862

Authors: Giovanna Flores-Mendoza, Noé Rodríguez-Rodríguez, Rosa M. Rubio, Iris K. Madera-Salcedo, Florencia Rosetti, José C. Crispín

Institutions: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Universidad Nacional Autónoma de México, Tecnológico de Monterrey

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950