Work

Identification of a Novel Hybrid Plasmid Encoding KPC-2 and Virulence Factors in Klebsiella pneumoniae Sequence Type 11

Year: 2021

Type: article

Abstract: Recent emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) coharboring bla KPC-2 and pLVPK-like virulence plasmids represented a novel clinical challenge. In the present study, we characterized a bla KPC-2 and virulence hybrid plasmid, designated pCRHV-C2244, from a clinical ST11-K64 CRKP strain. pCRHV-C2244 was non-self-transmissible due to incomplete conjugative elements but mobilizable together with a conjugative helper.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02435-20

Authors: Longyang Jin, Ruobing Wang, Hua Gao, Qi Wang, Hui Wang

Institution: Peking University People's Hospital

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Academy of Medical Sciences, National Natural Science Foundation of China