Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria
Year: 2021
Type: article
Abstract: infection did not increase circulating leptin levels, iRBC sequestration, tissue leptin production, and mTORC1 activity were positively correlated with CM in pediatric postmortem WAT. These data identify WAT sequestration as a trigger for leptin production with potential implications for pathogenesis of malaria infection, prognosis, and treatment.
Source: Science Advances
Authors: Pedro Mejia, J. Humberto Treviño-Villarreal, Mariana De Niz, Elamaran Meibalan, Alban Longchamp, Justin S. Reynolds, Lindsey B. Turnbull, Robert O. Opoka, Christian Roussilhon, Tobias Spielmann, C. Keith Ozaki, Volker T. Heussler, Karl B. Seydel, Terrie E. Taylor, Chandy C. John, Danny A. Milner, Matthias Marti, James R. Mitchell
Institutions: Harvard University, University of Bern, Wellcome Centre for Molecular Parasitology, University of Glasgow, Brigham and Women's Hospital, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Indiana University Indianapolis, Indiana University School of Medicine, Makerere University, Institut Pasteur, Department of Genomes & Genetics, Bernhard Nocht Institute for Tropical Medicine, Michigan State University, American Society for Clinical Pathology
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,500
Awards: G158121265, G8222298131, G8269333173
OpenAlex ID: W3136504599