Work

KCNQ3 is the principal target of retigabine in CA1 and subicular excitatory neurons

Year: 2021

Type: article

Abstract: Retigabine has risen to prominence as a first-in-class potassium channel opener approved by the Food and Drug Administration, with potential for treating multiple neurological disorders. Here, we demonstrate that KCNQ3 channels are the primary target of retigabine in excitatory neurons, as deleting these channels greatly diminishes the effect of retigabine in pyramidal neurons. Our data provide the first indication that retigabine controls neuronal firing properties primarily through KCNQ3 channels.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00564.2020

Authors: Nissi Varghese, Anna Lauritano, Maurizio Taglialatela, Anastasios V. Tzingounis

Institutions: University of Connecticut, University of Naples Federico II

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke