Work

Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task

Year: 2021

Type: article

Abstract: We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.

Source: eLife

DOI: 10.7554/elife.64327

Authors: Hongdian Yang, Bilal A. Bari, Jeremiah Y. Cohen, Daniel H. O’Connor

Institutions: University of California, Riverside, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Neural dynamics and brain function

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500

Funders: National Institutes of Health, National Institute of Mental Health, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke