Work

The role of LTBPs in TGF beta signaling

Year: 2021

Type: review

Abstract: The purpose of this review is to discuss the transforming growth factor beta (TGFB) binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences of LTBP loss in humans and mice. Finally, we consider a number of outstanding questions relating to LTBP function.

Source: Developmental Dynamics

DOI: 10.1002/dvdy.331

Authors: Daniel Rifkin, Nalani Sachan, Karan Singh, Elyse Sauber, George Tellides, Francesco Ramirez

Institutions: New York University, Yale University, Icahn School of Medicine at Mount Sinai

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute