Year: 2021
Type: article
Abstract: The lipolytic processing of triglyceride-rich lipoproteins within capillaries is mediated by LPL complexed to GPIHBP1, a protein of capillary endothelial cells (1). Angiopoietin-like protein 4 (ANGPTL4) plays an important role in regulating LPL activity, particularly in adipose tissue. Hydrogen-deuterium exchange experiments show that ANGPTL4 binds to sequences adjacent to the catalytic pocket of LPLs. This binding triggers progressive and irreversible unfolding of LPLs catalytic domain (2, 3). Importantly, ANGPTL4 catalyzes this unfolding.
Source: Journal of Lipid Research
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
Awards: Refining Physiologic Mechanisms for Intravascular Triglyceride Metabolism, New approaches for understanding lipid movement in health and disease, G2772487540, G2991559264, G331281257, G3752646566, G4193003059, G434337789, G5216767855, Investigating Mechanisms for Lipid Transport in Health and Disease, G7068895712, G822537046, G8315213195, G8556136195, G8981266112, International Doctoral Programme in Molecular Mechanisms of Disease
OpenAlex ID: W3137965592