Prediagnostic Antibody Responses to Fusobacterium nucleatum Proteins Are Not Associated with Risk of Colorectal Cancer in a Large U.S. Consortium
Year: 2021
Type: article
Study design: Observational Study
Abstract: Background: The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established. Methods: We conducted a nested case–control study of 8,126 participants in a consortium of 10 prospective cohorts in the United States. Results: Higher seroprevalence of any F. nucleatum antibody was observed among non-White participants (51.1%) compared with White participants (31.2%). We did not find any statistically significant association between seropositivity to any of the eight F. nucleatum proteins and colorectal cancer risk. Conclusions: Prediagnostic antibody responses to F. nucleatum proteins were not associated with the risk of colorectal cancer. Impact: Future studies may consider a more specific detection of the immunoglobulin isotypes or focus on examining F. nucleatum in stool or tissue samples.
Authors: Chun-Han Lo, William J. Blot, Lauren R. Teras, Kala Visvanathan, Loïc Le Marchand, Christopher A. Haiman, Yu Chen, Howard D. Sesso, Sylvia Wassertheil-Smoller, Lesley F. Tinker, Richard M. Peek, John D. Potter, Timothy L. Cover, Anne Zeleniuch-Jacquotte, Sonja I. Berndt, Tim Waterboer, Meira Epplein, Julia Butt, Mingyang Song
Institutions: Harvard University, Massachusetts General Hospital, Vanderbilt University Medical Center, American Cancer Society, Johns Hopkins University, University of Hawaii Cancer Center, USC Norris Comprehensive Cancer Center, New York University, Brigham and Women's Hospital, Albert Einstein College of Medicine, Fred Hutch Cancer Center, Vanderbilt University, Massey University, VA Tennessee Valley Healthcare System, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, German Cancer Research Center, Duke University, Duke Cancer Institute
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G1046522931, G1160275816, Structure and function of Helicobacter pylori VacA, G1734361364, G1851278524, G2111759553, G2214254730, Marine Omega-3 Fatty Acid, Tumor Immunity and Colorectal Cancer, Helicobacter Pylori and Gastrointestinal Biology, G2507688059, G3062349281, G3086620026, G3643850837, Dietary and Hormonal Determinants of Cancer in Women, G400951311, G4450071017, G4811508110, G4826281220, Physicians' Health Study II: Prevention Trial of Vitamins, Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer Prevention, TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'S, G7332203415, Cancer Epidemiology Cohort in Male Health Professionals, G8554986239, G8606882599, G9000109207, Molecular and Cellular Basis for Digestive Diseases, Type IV Protein Secretion in Helicobacter pylori, H. pylori-induced Inflammation and Gastric Cancer, Southern Community Cohort Study, RISK FACTORS FOR CVD IN WOMEN
OpenAlex ID: W3138055868