High KIFC1 expression is associated with poor prognosis in prostate cancer

Year: 2021

Type: article

Abstract: Kinesins play important roles in the progression and development of cancer. Kinesin family member C1 (KIFC1), a minus end-directed motor protein, is a novel Kinesin involved in the clustering of excess centrosomes found in cancer cells. Recently KIFC1 has shown to play a role in the progression of many different cancers, however, the involvement of KIFC1 in the progression of prostate cancer (PCa) is still not well understood. This study investigated the expression and clinical significance of KIFC1 in PCa by utilizing multiple publicly available datasets to analyze KIFC1 expression in patient samples. High KIFC1 expression was found to be associated with high Gleason score, high tumor stage, metastatic lesions, high ploidy levels, and lower recurrence-free survival. These results reveal that high KIFC1 levels are associated with a poor prognosis for PCa patients and could act as a prognostic indicator for PCa patients as well.

Source: Medical Oncology

DOI: 10.1007/s12032-021-01494-x

Authors: Laurie G. Kostecka, Athen Olseen, KiChang Kang, Gonzalo Torga, Kenneth J. Pienta, Sarah R. Amend

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,860

Funders: U.S. Department of Defense, Prostate Cancer Foundation, Johns Hopkins University, Patrick C. Walsh Prostate Cancer Research Fund, National Institutes of Health, National Cancer Institute, Congressionally Directed Medical Research Programs, DOD Prostate Cancer Research Program

OpenAlex ID: W3138463533