Associations between Serum Osteocalcin and Subjective Stress in People with Depression and Type II Diabetes
Year: 2020
Type: dissertation
Study design: Observational Study
Abstract: Low serum osteocalcin is a risk factor for type 2 diabetes mellitus (T2DM), and osteocalcin (OCN) release from bone is associated with an acute stress response. Both T2DM and stress are associated with depression. Here, a depressive episode was not associated with OCN concentrations among people with T2DM; however, higher concentrations of carboxylated OCN (cOCN) were associated with higher perceived stress among participants with depression (r=0.546, p=0.013) and T2DM. Controlling for age, sex, body mass index, glycemic control (HbA1c), insulin resistance (homeostatic model), depression, and antidepressant use, carboxylated OCN was associated with perceived stress (F=9.602, p=0.003), and this relationship was stronger in those with depression (depression × cOCN interaction F=4.702, p=0.033). The results identify circulating OCN as a neuroendocrine marker associated with chronic stress among people with T2DM experiencing a depressive episode.
Source: TSpace (University of Toronto)
Author: Michelle Nguyen
Language: English
Subfield: Behavioral Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: Sunnybrook Research Institute, Toronto Rehabilitation Institute, University of Toronto, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Banting and Best Diabetes Centre, University of Toronto, National Institute of Diabetes and Digestive and Kidney Diseases
OpenAlex ID: W3138610937