Work

DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1

Year: 2021

Type: article

Abstract: cells to poly (ADP-ribose) polymerase (PARP) inhibition similar to BRCA1 deficiency. These data demonstrate how Sp1 integrates the cell cycle and DSB repair pathway choice to favor NHEJ.

Source: Cell Reports

DOI: 10.1016/j.celrep.2021.108840

Authors: Michelle L. Swift, Kate Beishline, Samuel Flashner, Jane Azizkhan-Clifford

Institution: Drexel University

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,200

Funder: College of Medicine, Drexel University

OpenAlex ID: W3138720169

FWCI: 1.818

Cites: 66

Cited by: 41

Related to: 10