Effects of Cannabidiol and delta-9-Tetrahydrocannabinol in The Elevated Plus Maze and Forced Swim Tests
Year: 2019
Type: dissertation
Abstract: The effects of THC, CBD and a combination of CBD and THC (15:1) were tested in mice models of anxiety (elevated plus maze EPM) and depression (forced swim test FST). Adult, male CD1 mice were injected intraperitoneally (I.P.) with CBD (0-120mg/kg), THC (0-8mg/), CBD + THC (up to 120+8mg/kg), diazepam (0, 2.5mg/kg) or imipramine (0, 30mg/kg). EPM ran for 5mins, FST for 6mins, and open field test for 10mins. CBD was injected 30 or 60mins prior to testing and THC was injected 30mins prior. CBD decreased immobility time in FST. THC increased time spent in the open arms in EPM, and decreased immobility time in FST. The combination of CBD and THC was better than CBD or THC alone in FST at 30mins. CBD did not show anxiolytic effects but showed anti-depressant effects. THC had both anxiolytic and antidepressant effects at some doses. CBD and THC combined might be useful in patients with anxiety and depression.
Source: TSpace (University of Toronto)
Author: Junhan Liu
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3139411881