Year: 2021
Type: article
Abstract: The purpose of this study is to synthesize new boron containing carrier compound for Boron Neutron Capture Therapy (BNCT) which is two-component radiation therapy method that especially is promising for the treatment of brain tumors and is being actively researched in many countries.For this research hyperbranched polyester (HBP), bifunctional p-carborane and carborane-functionalized HBP were synthesized.Dipentaerythritol was chosen as a core molecule of the HBP and esterified with dimethylol propionic acid.Observed characteristic ester bands and OH stretching band in the FTIR spectrum and the methyl & methylene peaks in the 1 H NMR spectrum of HBP indicated that hyperbranched polyester synthesis was done successfully.A bifunctionalized p-carborane containing an acid group and a benzyl ether protected alcohol was prepared in three-step reactions.As a result of these reactions, a bifunctionalized p-carborane compound was produced with 60% yield.Then, the HBP was esterified with the bifunctional p-carborane.The characterization of the synthesized compounds was determined by FTIR and NMR spectra.The synthesis of carborane-functionalized HBP was confirmed by disappearance of HBP's OH groups and B-H stretching band observed in the FTIR spectrum of carborane-functionalized HBP and in addition, appearance of proton signals of HBP core, carborane linker and peripheral-protecting groups in the 1 H-NMR spectrum.Finally, synthesized water-soluble carborane-containing HB carrying many boron atoms should be served as potential BNCT agents.
Source: Journal of Boron
Language: English
Topic: Boron Compounds in Chemistry
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3139478963