Work

Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines

Year: 2021

Type: article

Abstract: The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired one of the most efficient vaccine development campaigns in human history. A key aspect of COVID-19 mRNA vaccines is the use of the modified nucleobase N1-methylpseudouridine (m1Ψ) to increase their effectiveness. In this Outlook, we summarize the development and function of m1Ψ in synthetic mRNAs. By demystifying how a novel element within these medicines works, we aim to foster understanding and highlight future opportunities for chemical innovation.

Source: ACS Central Science

DOI: 10.1021/acscentsci.1c00197

Authors: Kellie D. Nance, Jordan L. Meier

Institutions: National Institutes of Health, National Cancer Institute, Center for Cancer Research

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Cancer Institute