Year: 2018
Type: dissertation
Abstract: Fetal growth restriction is prevalent throughout South Asia; yet, causes remain unclear. Parathyroid hormone (PTH) regulates calcium homeostasis and bone turnover. We investigated the association of maternal PTH with newborn anthropometry and regulators of PTH, in a pregnancy cohort in Dhaka, Bangladesh. This study was cross-sectional, using data from 492 participants enrolled in a prenatal vitamin D supplementation trial. The primary outcome was length-for-gestational-age z-scores (LAZ). Secondary outcomes included weight-for-gestational age z-scores (WAZ), head-circumference-for-gestational age z-scores (HCAZ), and rump-to-knee length. Contrary to our hypothesis, maternal PTH was positively associated with WAZ in univariate and multivariable models; however, the effect was small. In multivariable and path analysis models, vitamin D supplementation suppressed PTH, and fibroblast-like growth factor-23 (FGF23) was positively associated with PTH. This was the first study to identify an association between maternal FGF23 and newborn size. Future studies should further characterize the effect of prenatal FGF23 on birth size.
Source: TSpace (University of Toronto)
Author: Huma Qamar
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3140525917