Work

Author response: Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

Year: 2021

Type: peer-review

Abstract: Monitoring SHP2 phosphoproteome dynamics identifies new substrate sites and sites protected from dephosphorylation by its SH2 domains, highlighting distinct scaffolding and catalytic activities in effecting a transmembrane signaling response.

DOI: 10.7554/elife.64251.sa2

Authors: Vidyasiri Vemulapalli, Lily A Chylek, Alison Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Jonathan LaRochelle, Kartik Subramanian, Ruili Cao, Kimberley Stegmaier, Morvarid Mohseni, Matthew J LaMarche, Michael G Acker, Peter K Sorger, Steven P Gygi, Stephen C Blacklow

Institutions: Harvard University, Dana-Farber Cancer Institute, University of Copenhagen, Novo Nordisk Foundation, Novartis (Switzerland), Novartis Institutes for BioMedical Research

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W3140928709

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